We review studies from our laboratories using different molecular tools to characterize the
Amerindian, European and African ancestry of Brazilians. Initially we used uniparental DNA …

Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer
susceptibility; its protein structure and acetylation capacity results from the polymorphism's …

Long QT syndromes can be either acquired or congenital. Drugs are one of the many
etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used …

Purpose To review recent pharmacogenomics studies on breast cancer patients undergoing
tamoxifen therapy, highlighting how our knowledge on cytochrome P450 2D6 (CYP2D6) can …

In genes related to drug pharmacokinetics, molecular variations determine interindividual
variability in the therapeutic efficacy and adverse drug reactions. The assessment of single …

Background Clopidogrel is an inactive prodrug, it catalyzed into its active form by
Cytochrome 450 and Paraoxonase-1 (PON-1). polymorphisms of genes encoding these …

Interethnic variability in the drug-metabolizing capacity of CYP450 enzymes may lead to
discrepancies in the relationship between genotypes and phenotypes worldwide. The …

Human pigmentation is a complex trait, probably involving more than 100 genes. Predicting
phenotypes using SNPs present in those genes is important for forensic purpose. For this …

The CYP2C19 gene, located in the CYP2C cluster, encodes the major drug metabolism
enzyme CYP2C19. This gene is highly polymorphic and no-function (CYP2C19* 2 and …

Background This study used therapeutic drug monitoring (TDM) and CYP2C19 gene
polymorphism analysis to explore the efficacy and safety of different doses of voriconazole …