Polyphosphate kinase 2 (PPK2) enzymes: structure, function, and roles in bacterial physiology and virulence
Inorganic polyphosphate (polyP) has been implicated in an astonishing array of biological
functions, ranging from phosphorus storage to molecular chaperone activity to bacterial …
functions, ranging from phosphorus storage to molecular chaperone activity to bacterial …
Inorganic polyphosphate in host and microbe biology
MQ Bowlin, MJ Gray - Trends in microbiology, 2021 - cell.com
Inorganic polyphosphate (polyP) is produced by both bacteria and their eukaryotic hosts,
and it appears to play multiple important roles in the interactions between those organisms …
and it appears to play multiple important roles in the interactions between those organisms …
Polyphosphate kinase-1 regulates bacterial and host metabolic pathways involved in pathogenesis of Mycobacterium tuberculosis
Inorganic polyphosphate (polyP) is primarily synthesized by Polyphosphate Kinase-1 (PPK-
1) and regulates numerous cellular processes, including energy metabolism, stress …
1) and regulates numerous cellular processes, including energy metabolism, stress …
Mycobacterium tuberculosis strain with deletions in menT3 and menT4 is attenuated and confers protection in mice and guinea pigs
The genome of Mycobacterium tuberculosis encodes for a large repertoire of toxin-antitoxin
systems. In the present study, MenT3 and MenT4 toxins belonging to MenAT subfamily of TA …
systems. In the present study, MenT3 and MenT4 toxins belonging to MenAT subfamily of TA …
Polyphosphate is an extracellular signal that can facilitate bacterial survival in eukaryotic cells
R Rijal, LA Cadena, MR Smith… - Proceedings of the …, 2020 - National Acad Sciences
Polyphosphate is a linear chain of phosphate residues and is present in organisms ranging
from bacteria to humans. Pathogens such as Mycobacterium tuberculosis accumulate …
from bacteria to humans. Pathogens such as Mycobacterium tuberculosis accumulate …
Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures
AE Parnell, S Mordhorst, F Kemper… - Proceedings of the …, 2018 - National Acad Sciences
Inorganic polyphosphate is a ubiquitous, linear biopolymer built of up to thousands of
phosphate residues that are linked by energy-rich phosphoanhydride bonds. Polyphosphate …
phosphate residues that are linked by energy-rich phosphoanhydride bonds. Polyphosphate …
Progress report: Antimicrobial drug discovery in the resistance era
Antibiotic resistance continues to be a most serious threat to public health. This situation
demands that the scientific community increase their efforts for the discovery of alternative …
demands that the scientific community increase their efforts for the discovery of alternative …
Structural insights into substrate selectivity and activity of bacterial polyphosphate kinases
BP Nocek, AN Khusnutdinova, M Ruszkowski… - ACS …, 2018 - ACS Publications
Polyphosphate (polyP) kinases are widely conserved enzymes with importance in basic
bacterial metabolism and virulence in many pathogens. However, the molecular …
bacterial metabolism and virulence in many pathogens. However, the molecular …
a dual-specificity Inhibitor targets polyphosphate kinase 1 and 2 enzymes to attenuate virulence of Pseudomonas aeruginosa
The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of nosocomial
infections, which are becoming increasingly difficult to treat due to antibiotic resistance …
infections, which are becoming increasingly difficult to treat due to antibiotic resistance …
Insights on recent approaches in drug discovery strategies and untapped drug targets against drug resistance
Background Despite the various strategies undertaken in the clinical practice, the mortality
rate due to antibiotic-resistant microbes has been markedly increasing worldwide. In …
rate due to antibiotic-resistant microbes has been markedly increasing worldwide. In …