Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …

Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

Nowadays, mass spectrometry‐based proteomics is carried out primarily in a bottom‐up
fashion, with peptides obtained after proteolytic digest of a whole proteome lysate as the …

Inflammasomes represent a group of protein complexes that contribute to host defense
against pathogens and repair processes upon the induction of inflammation. However …

Because the majority of bacterial species divide by binary fission, and do not have
distinguishable somatic and germline cells, they could be considered to be immortal …

The origins and evolution of the ribosome, 3–4 billion years ago, remain imprinted in the
biochemistry of extant life and in the structure of the ribosome. Processes of ribosomal RNA …

A central goal in biochemistry is to explain the causes of protein sequence, structure, and
function. Mainstream approaches seek to rationalize sequence and structure in terms of their …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

Enzymes, as nature's catalysts, speed up the very reactions that make life possible.
Hydrolytic enzymes are a particularly important enzyme class responsible for the catalytic …