[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs

M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function

RJ Roman - Physiological reviews, 2002 - journals.physiology.org
Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Thematic Review Series: proteomics. An integrated omics analysis of eicosanoid biology1 [S]

MW Buczynski, DS Dumlao, EA Dennis - Journal of lipid research, 2009 - ASBMB
Eicosanoids have been implicated in a vast number of devastating inflammatory conditions,
including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different …

Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation

VC Tam, O Quehenberger, CM Oshansky, R Suen… - Cell, 2013 - cell.com
Bioactive lipid mediators play a crucial role in the induction and resolution of inflammation.
To elucidate their involvement during influenza infection, liquid chromatography/mass …

Synthesis and significance of arachidonic acid, a substrate for cyclooxygenases, lipoxygenases, and cytochrome P450 pathways in the tumorigenesis of glioblastoma …

J Korbecki, E Rębacz-Maron, P Kupnicka, D Chlubek… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

Cytochrome P450 pathways of arachidonic acid metabolism

DL Kroetz, DC Zeldin - Current opinion in lipidology, 2002 - journals.lww.com
Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …

Dietary modulation of oxylipins in cardiovascular disease and aging

SPB Caligiuri, M Parikh… - American Journal …, 2017 - journals.physiology.org
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …

Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections

VC Tam - Seminars in immunology, 2013 - Elsevier
Bioactive lipid mediators play crucial roles in promoting the induction and resolution of
inflammation. Eicosanoids and other related unsaturated fatty acids have long been known …

Involvement of proinflammatory arachidonic acid (Ara) derivatives in Crohn's disease (Cd) and ulcerative colitis (Uc)

J Kikut, M Mokrzycka, A Drozd… - Journal of clinical …, 2022 - mdpi.com
Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been
observed, especially among children and adolescents. Currently, few studies focus on the …

Elucidation for the pharmacological effects and mechanism of Shen Bai formula in treating myocardial injury based on energy metabolism and serum metabolomic …

H Song, J Ren, L Yang, H Sun, G Yan, Y Han… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Shen Bai formula (SBF) is a proven effective
traditional Chinese medicine for treating viral myocarditis (VMC) sequelae in clinic, and …