Bone morphogenetic protein-2 in development and bone homeostasis

D Halloran, HW Durbano, A Nohe - Journal of developmental biology, 2020 - mdpi.com
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

M Wu, S Wu, W Chen, YP Li - Cell Research, 2024 - nature.com
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …

[HTML][HTML] TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

M Wu, G Chen, YP Li - Bone research, 2016 - nature.com
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling
has fundamental roles in both embryonic skeletal development and postnatal bone …

BMP signalling in skeletal development, disease and repair

VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Progress of Wnt signaling pathway in osteoporosis

Y Gao, N Chen, Z Fu, Q Zhang - Biomolecules, 2023 - mdpi.com
Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density
diminishing, and degeneration of bone microstructure, which is accompanied by a tendency …

[HTML][HTML] Bone Morphogenetic Protein (BMP) signaling in development and human diseases

RN Wang, J Green, Z Wang, Y Deng, M Qiao… - Genes & diseases, 2014 - Elsevier
Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …

[HTML][HTML] TGF-β and BMP signaling in osteoblast differentiation and bone formation

G Chen, C Deng, YP Li - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is
involved in a vast majority of cellular processes and is fundamentally important throughout …

Osteoblast and osteocyte: games without frontiers

M Capulli, R Paone, N Rucci - Archives of biochemistry and biophysics, 2014 - Elsevier
The portrait of osteoblasts and osteocytes has been subjected to a revision, since a large
body of evidence is attributing these cells amazing roles both inside and outside the bone …

Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

AY Clark, KE Martin, JR García, CT Johnson… - Nature …, 2020 - nature.com
Stem cell therapies are limited by poor cell survival and engraftment. A hurdle to the use of
materials for cell delivery is the lack of understanding of material properties that govern …

TGF-β family signaling in mesenchymal differentiation

I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …