Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive
and fatal neurodegenerative disease that leads to a loss of muscle control due to nerve cells …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Abstract Introduction/Aims Trials incorporating placebo‐to‐active treatment crossover are
encouraged in fatal conditions like amyotrophic lateral sclerosis (ALS) but may …

Amyotrophic lateral sclerosis (ALS) is caused by the progressive degeneration of motor
neurons in the spinal cord, the brain stem, and the motor cortex. So far, there is still a lack of …

Edaravone, the first known free radical scavenger, has demonstrated cellular protective
properties in animals and humans. Owing to its antioxidant activity, edaravone modulates …

Neuromuscular disorders (NMDs) encompass a large heterogeneous group of hereditary
and acquired diseases primarily affecting motor neurons, peripheral nerves, and the skeletal …

Oxygen is essential to the human life and life of all aerobic organisms. The complete
oxidation of nutrients for the biological energy supply is one of the most important …

Abstract Amyotrophic Lateral Sclerosis (ALS) leads to functional capacity decline,
generating great impact in quality of life. Quality of life is directly related to physical integrity …

Glutamate is the major excitatory neurotransmitter in the central nervous system. Beyond this
function, glutamate also plays a key role in intermediary metabolism in all organs and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive degeneration of motor neurons, leading to muscle atrophy, paralysis and …