The role of PINK1–Parkin in mitochondrial quality control
DP Narendra, RJ Youle - Nature Cell Biology, 2024 - nature.com
Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …
Mitochondrial signalling and homeostasis: from cell biology to neurological disease
JJ Collier, M Oláhová, TG McWilliams… - Trends in …, 2023 - cell.com
Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …
Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
AT Moehlman, G Kanfer, RJ Youle - PLoS Genetics, 2023 - journals.plos.org
The early pathogenesis and underlying molecular causes of motor neuron degeneration in
Parkinson's Disease (PD) remains unresolved. In the model organism Drosophila …
Parkinson's Disease (PD) remains unresolved. In the model organism Drosophila …
FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo
A Sanchez-Martinez, A Martinez, AJ Whitworth - PLoS Biology, 2023 - journals.plos.org
Functional analyses of genes linked to heritable forms of Parkinson's disease (PD) have
revealed fundamental insights into the biological processes underpinning pathogenic …
revealed fundamental insights into the biological processes underpinning pathogenic …
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models
A Martinez, A Sanchez-Martinez, JT Pickering… - Molecular …, 2024 - Springer
Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be
key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's …
key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's …
[HTML][HTML] Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression
Y Yin, H Shen - Toxicology, 2023 - Elsevier
Paraquat (PQ) poisoning can result in multiple organ dysfunction syndrome, mainly
manifesting as acute lung injury and acute respiratory distress syndrome. No specific cure …
manifesting as acute lung injury and acute respiratory distress syndrome. No specific cure …
Alterations of PINK1-PRKN signaling in mice during normal aging
Z Baninameh, JO Watzlawik, X Hou… - Autophagy …, 2024 - Taylor & Francis
The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged
mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this …
mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this …