Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Pressure-dependent chronotropy of murine lymphatic collecting vessels relies on the
activation of the Ca2+-activated chloride channel encoded by Anoctamin 1 (Ano1) in …

Defective protein quality control (PQC) systems are implicated in multiple diseases.
Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant …

To maintain healthy mitochondrial enzyme content and function, mitochondria possess a
complex protein quality control system, which is composed of different endogenous sets of …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Background Vascular smooth muscle cell (VSMC) proliferation is involved in many types of
arterial diseases, including neointima hyperplasia, in which Ca2+ has been recognized as a …