Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Laulimalide and peloruside A are microtubule‐stabilizing agents (MSAs), the mechanism of
action on microtubules of which is poorly defined. Here, using X‐ray crystallography it is …

Cancer is a multifactorial disease and its genesis and progression are extremely complex.
The biggest problem in the anticancer drug development is acquiring of multidrug resistance …

Assessing the functional outcome of protein interactions in structural terms is a goal of
structural biology, however most techniques have a limited capacity for making structure …

Amide H/D exchange (HDX) mass spectrometry (MS) is widely used for protein structural
studies. Traditionally, this technique involves protein labeling in D2O, followed by acid …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …

Microtubules (MTs) are a highly successful target for anticancer therapy. MT-stabilizing
agents (MSAs) bind to MTs, promoting their polymerization, blocking mitosis, and causing …

Natural products, especially microtubule-binding natural products, play important roles in the
war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to …