Towards precision medicine: Omics approach for COVID-19

X Cen, F Wang, X Huang, D Jovic, F Dubee… - Biosafety and …, 2023 - mednexus.org
The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on human
society. Beginning with genome surveillance of severe acute respiratory syndrome …

[HTML][HTML] Single-cell RNA sequencing to understand host-virus interactions

JT Chang, LB Liu, PG Wang, J An - Virologica Sinica, 2024 - Elsevier
Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus
transcripts and host-virus interactions at single-cell resolution. This review summarizes the …

Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of …

Y Zhu, Y Zhang, S He, S Yi, H Feng, X Xia… - Journal of …, 2024 - Springer
Background Understanding the mechanism behind sepsis-associated encephalopathy
(SAE) remains a formidable task. This study endeavors to shed light on the complex cellular …

Differential activation of programmed cell death in patients with severe SARS-CoV-2 infection

AN Riegler, P Benson, K Long, SM Leal Jr - Cell Death Discovery, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe lower
airway disease and death in a subset of patients. Knowledge on the relative contribution of …

sc-ImmuCC: hierarchical annotation for immune cell types in single-cell RNA-seq

Y Jiang, Z Chen, N Han, J Shang, A Wu - Frontiers in Immunology, 2023 - frontiersin.org
Accurately identifying immune cell types in single-cell RNA-sequencing (scRNA-Seq) data is
critical to uncovering immune responses in health or disease conditions. However, the high …

Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients

Y Leyfman, N Emmanuel, GP Menon, M Joshi… - Journal of Hematology & …, 2023 - Springer
Cancer patients, due to their immunocompromised status, are at an increased risk for severe
SARS-CoV-2 infection. Since severe SARS-CoV-2 infection causes multiple organ damage …

[HTML][HTML] Computational identification of differentially-expressed genes as suggested novel COVID-19 biomarkers: A bioinformatics analysis of expression profiles

V Di Salvatore, E Crispino, A Maleki, G Nicotra… - Computational and …, 2023 - Elsevier
COVID-19 was declared a pandemic in March 2020, and since then, it has not stopped
spreading like wildfire in almost every corner of the world, despite the many efforts made to …

[HTML][HTML] Single-cell genomics for investigating pathogenesis of inflammatory diseases

S Jung, JS Lee - Molecules and cells, 2023 - Elsevier
Recent technical advances have enabled unbiased transcriptomic and epigenetic analysis
of each cell, known as “single-cell analysis”. Single-cell analysis has a variety of technical …

Single‐cell transcriptomic atlas of distinct early immune responses induced by SARS‐CoV‐2 Proto or its variants in rhesus monkey

Y Yang, T Du, W Yu, Y Zhou, C Yang, D Kuang… - MedComm, 2023 - Wiley Online Library
Immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2) infection play a critical role in the pathogenesis and outcome of coronavirus disease …

Neuroimmune mechanisms underlying post-acute sequelae of SARS-CoV-2 (PASC) pain, predictions from a ligand-receptor interactome

JB Lesnak, K Mazhar, TJ Price - Current Rheumatology Reports, 2023 - Springer
Abstract Purpose of Review Individuals with post-acute sequelae of SARS-CoV-2 (PASC)
complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces …