The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …

Purpose: Bisphosphonates are currently the most important class of antiresorptive agents
used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and …

Bisphosphonates (BPs) are widely used in the treatment of diseases associated with
excessive osteoclast-mediated bone resorption, such as osteoporosis. Although several …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Bisphosphonates are effective antiresorptive agents owing to their bone‐targeting property
and ability to inhibit osteoclasts. It remains unclear, however, whether any non‐osteoclast …

Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …

The Golgi apparatus-complex is a highly dynamic organelle which is considered the “heart”
of intracellular transportation. Since its discovery by Camillo Golgi in 1873, who described it …

Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The
number and activity of osteoclasts are often enhanced by tumors. However, the origin of …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

Nitrogen‐containing bisphosphonates (N‐BPs) are effective antiosteolytic agents in patients
with multiple myeloma. Preclinical studies have also demonstrated that these agents have …