The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Key pathological, including oncogenic, signaling pathways regulate the canonical functions
of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling …

Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

The abscission checkpoint contributes to the fidelity of chromosome segregation by delaying
completion of cytokinesis (abscission) when there is chromatin lagging in the intercellular …

Methionine (Met) can be oxidized to methionine sulfoxide (MetO), which exist as R-and S-
diastereomers. Present in all three domains of life, methionine sulfoxide reductases (MSR) …

In response to chromatin bridges, the abscission checkpoint delays completion of
cytokinesis to prevent chromosome breakage or tetraploidization. Here, we show that …

Actin is the most abundant protein in almost all the eukaryotic cells. Actin amino acid
sequences are highly conserved and have not changed a lot during the progress of …

Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting
the daughter cells and concludes cell division. In different animal cells, it is well established …

During cytokinesis, the intercellular bridge (ICB) connecting the daughter cells experiences
pulling forces, which delay abscission by preventing the assembly of the ESCRT scission …

Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …