Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic

SW Attwood, SC Hill, DM Aanensen… - Nature Reviews …, 2022 - nature.com
Determining the transmissibility, prevalence and patterns of movement of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding …

Fitness, growth and transmissibility of SARS-CoV-2 genetic variants

E Volz - Nature Reviews Genetics, 2023 - nature.com
The massive scale of the global SARS-CoV-2 sequencing effort created new opportunities
and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment …

[PDF][PDF] Genomic sequencing of SARS-CoV-2: a guide to implementation for maximum impact on public health, 8 January 2021

World Health Organization - 2021 - apps.who.int
The year 2020 was a turning point in history and in global health. The COVID-19 pandemic
has highlighted the potential for deadly epidemic-prone diseases to overwhelm our …

Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research

F Hufsky, K Lamkiewicz, A Almeida… - Briefings in …, 2021 - academic.oup.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of
the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of …

Integrating fossil observations into phylogenetics using the fossilized birth–death model

AM Wright, DW Bapst, J Barido-Sottani… - Annual Review of …, 2022 - annualreviews.org
Over the past decade, a new set of methods for estimating dated trees has emerged.
Originally referred to as the fossilized birth–death (FBD) process, this single model has …

Estimates of early outbreak-specific SARS-CoV-2 epidemiological parameters from genomic data

TG Vaughan, J Scire, SA Nadeau… - Proceedings of the …, 2024 - National Acad Sciences
We estimate the basic reproductive number and case counts for 15 distinct Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks, distributed across 11 …

Unifying phylogenetic birth–death models in epidemiology and macroevolution

A MacPherson, S Louca, A McLaughlin… - Systematic …, 2022 - academic.oup.com
Birth–death stochastic processes are the foundations of many phylogenetic models and are
widely used to make inferences about epidemiological and macroevolutionary dynamics …

Fundamental identifiability limits in molecular epidemiology

S Louca, A McLaughlin, A MacPherson… - Molecular biology …, 2021 - academic.oup.com
Viral phylogenies provide crucial information on the spread of infectious diseases, and many
studies fit mathematical models to phylogenetic data to estimate epidemiological parameters …

Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics

BD Hollingsworth, ND Grubaugh, BP Lazzaro… - PLoS …, 2023 - journals.plos.org
Several aspects of mosquito ecology that are important for vectored disease transmission
and control have been difficult to measure at epidemiologically important scales in the field …

Development of phylodynamic methods for bacterial pathogens

DJ Ingle, BP Howden, S Duchene - Trends in Microbiology, 2021 - cell.com
Phylodynamic methods have been essential to understand the interplay between the
evolution and epidemiology of infectious diseases. To date, the field has centered on …