Mechanisms regulating the CRISPR-Cas systems
M Zakrzewska, M Burmistrz - Frontiers in Microbiology, 2023 - frontiersin.org
The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR
associated proteins) is a prokaryotic system that enables sequence specific recognition and …
associated proteins) is a prokaryotic system that enables sequence specific recognition and …
AcrPred: A hybrid optimization with enumerated machine learning algorithm to predict Anti-CRISPR proteins
CRISPR-Cas, as a tool for gene editing, has received extensive attention in recent years.
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
The 2022 Nucleic Acids Research database issue and the online molecular biology database collection
DJ Rigden, XM Fernández - Nucleic acids research, 2022 - academic.oup.com
Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …
87 papers reporting on new databases and 85 updates from resources previously published …
CRISPR-based approaches for gene regulation in non-model bacteria
SN Call, LB Andrews - Frontiers in genome editing, 2022 - frontiersin.org
CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …
ubiquitous approaches to control gene expression in bacteria due to their simple design and …
CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing
F Zhou, X Yu, R Gan, K Ren, C Chen… - Nucleic acids …, 2023 - academic.oup.com
The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
[HTML][HTML] Thousands of small, novel genes predicted in global phage genomes
Summary Small genes (< 150 nucleotides) have been systematically overlooked in phage
genomes. We employ a large-scale comparative genomics approach to predict> 40,000 …
genomes. We employ a large-scale comparative genomics approach to predict> 40,000 …
Applications of anti-CRISPR proteins in genome editing and biotechnology
C Kraus, EJ Sontheimer - Journal of Molecular Biology, 2023 - Elsevier
In the ten years since the discovery of the first anti-CRISPR (Acr) proteins, the number of
validated Acrs has expanded rapidly, as has our understanding of the diverse mechanisms …
validated Acrs has expanded rapidly, as has our understanding of the diverse mechanisms …
Current updates of CRISPR/Cas system and anti-CRISPR proteins: innovative applications to improve the genome editing strategies
Abstract The Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR-associated sequence (CRISPR/Cas) system is a cutting-edge genome …
(CRISPR)/CRISPR-associated sequence (CRISPR/Cas) system is a cutting-edge genome …
A phage foundry framework to systematically develop viral countermeasures to combat antibiotic-resistant bacterial pathogens
VK Mutalik, AP Arkin - Iscience, 2022 - cell.com
At its current rate, the rise of antimicrobial-resistant (AMR) infections is predicted to paralyze
our industries and healthcare facilities while becoming the leading global cause of loss of …
our industries and healthcare facilities while becoming the leading global cause of loss of …
Anti-CRISPRdb v2. 2: an online repository of anti-CRISPR proteins including information on inhibitory mechanisms, activities and neighbors of curated anti-CRISPR …
C Dong, X Wang, C Ma, Z Zeng, DK Pu, S Liu… - Database, 2022 - academic.oup.com
We previously released the Anti-CRISPRdb database hosting anti-CRISPR proteins (Acrs)
and associated information. Since then, the number of known Acr families, types, structures …
and associated information. Since then, the number of known Acr families, types, structures …