Isocyanide (isonitrile) chemistry began in 1859 when Lieke obtained the first compound of
this type. 1 In 1958, isocyanides became generally available by dehydration of formamides …

The building block approach was identified as a useful alternative to the commonly used
Bücherer− Berg method for the preparation of cyclic unusual α-amino acid derivatives. The …

Conformationally constrained amino acids (AAs) have been the focus of both synthetic and
medicinal chemistry, particularly as they apply to the design of novel peptides. 1 Rigidified …

Here we describe several useful strategies to a variety of unusual α-amino acid derivatives
and peptides based on “building block” approach. These building blocks are suitable for …

Enyne metathesis (EM) has widely been used to prepare various synthetic and natural
products. Further, a sequential use of EM and Diels–Alder (DA) reactions generates highly …

A novel heteroannulation reaction between α‐amino imides and in situ generated arynes
has been developed for the synthesis of 2, 2‐disubstituted indolin‐3‐ones. An …

The benzocyclobutene (BCB) moiety is present in several bioactive natural products and
medicinally interesting molecules. BCB is also a valuable synthon for building a variety of …

This report provides an overview of the practical methods for preparing symmetrically α, α-
disubstituted α-amino acids and their derivatives. Despite the growing application of this …

In our pursuit of developing novel analogs of anthracyclines with enhanced antitumor
efficacy and safety, we have designed a synthesis scheme for 4, 11-dihydroxy-5, 10 …

A new approach for modification of phenylalanine peptides by suzuki–miyaura coupling
reaction - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …