Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …

Cancer is the leading disease-related cause of death in children in developed countries.
Arising in the context of actively growing tissues, childhood cancers are fundamentally …

GATA family proteins play essential roles in development of many cell types, including
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …

Childhood leukaemia is the principal subtype of paediatric cancer and, despite success in
treatment, its causes remain enigmatic. A plethora of candidate environmental exposures …

Updating the classification of hematologic neoplasia with germline predisposition, pediatric
myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) is critical …

Most scientists agree that the majority of human solid malignant tumors are characterized by
chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of …

El síndrome de Down es la cromosomopatía más común del ser humano, con una
frecuencia de 1 en 650 recién nacidos vivos. Las manifestaciones clínicas son muy …

Abstract Ets-related gene (ERG), which encodes a member of the Ets family of transcription
factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in …