Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …

The emergence and prevalence of mobile colistin resistance gene mcr have dramatically
compromised the clinical efficacy of colistin, a cyclopeptide antibiotic considered to be the …

The increasingly severe bacterial resistance worldwide pushes people to discover and
design potential antibacterial drugs unavoidably. In this work, a series of short, mirror …

Polymyxins have resurged as the last-resort antibiotics against multidrug-resistant
Acinetobacter baumannii. As reports of polymyxin resistance in A. baumannii with …

Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters
for the delivery of cargo such as virulence and antibiotic resistance factors. OMVs play a key …

The pentose phosphate pathway (PPP) plays a key role in many metabolic functions,
including the generation of NADPH, biosynthesis of nucleotides, and carbon homeostasis. In …

Klebsiella pneumoniae is an opportunistic Gram-negative pathogen causing nosocomial
infections. K. pneumoniae rapidly acquires antibiotic resistance and is known as a reservoir …

Novel antimicrobial strategies are urgently needed to treat extensively drug‐resistant (XDR)
bacterial infections due to the high mortality rate and lack of effective therapeutic agents …

The global issue of antibiotic resistance is increasingly severe, highlighting the urgent
necessity for the development of new antibiotics. Brevicidine, a natural cyclic lipopeptide …

The escalating antimicrobial resistance crisis urges the development of new antibacterial
treatments with innovative mechanisms of action, particularly against the critical priority …