Compounds with anti-influenza activity: present and future of strategies for the optimal
treatment and management of influenza. Part I: influenza life-cycle and currently available …

A severe course of acute respiratory disease caused by influenza A virus (IAV) infection is
often linked with subsequent bacterial superinfection, which is difficult to cure. Thus …

ABSTRACT The polymerase basic 2 (PB2) subunit of the RNA polymerase complex of
seasonal human influenza A viruses has been shown to localize to the mitochondria …

The importance of antiviral CD8+ T cell recognition of alternative reading frame (ARF)–
derived peptides is uncertain. In this study, we describe an epitope (NS1-ARF2 1–8) present …

RIG-I plays an essential role in the duck innate immune response to influenza infection. RIG-
I engages the critical adaptor protein mitochondrial antiviral signaling (MAVS) to activate the …

Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces
samples (n= 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and …

Highly pathogenic influenza A viruses (IAV) from avian hosts were first reported to directly
infect humans 20 years ago. However, such infections are rare events, and our …

The greatest diversity of influenza A virus (IAV) is found in wild aquatic birds of the orders
Anseriformes and Charadriiformes. In these birds, IAV replication occurs mostly in the …

Influenza A viruses (IAV) are members of the Orthomyxoviridae family of negative-sense
RNA viruses. The greatest diversity of IAV strains is found in aquatic birds, but a subset of …

Influenza A virus PB1-F2, encoding a multi-functional protein, is regarded as a virulent gene.
Variation in expression pattern and protein stability among PB1-F2 proteins derived from …