Oxidative stress and hypertension
KK Griendling, LL Camargo, FJ Rios… - Circulation …, 2021 - Am Heart Assoc
A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …
animal models of hypertension but remains elusive in humans. While initial studies focused …
NADPH oxidases: an overview from structure to innate immunity-associated pathologies
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
Nox family NADPH oxidases: molecular mechanisms of activation
RP Brandes, N Weissmann, K Schröder - Free Radical Biology and …, 2014 - Elsevier
NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS). Numerous homologue-specific mechanisms control the activity of this …
species (ROS). Numerous homologue-specific mechanisms control the activity of this …
[HTML][HTML] Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation
S Huang, LL Wang, NN Xue, C Li, HH Guo, TK Ren… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Inducing cancer differentiation is a promising approach to treat cancer. Here, we
identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and …
identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and …
Mechanisms of oxidative stress and therapeutic targets following intracerebral hemorrhage
Z Yao, Q Bai, G Wang - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS)
following intracerebral hemorrhage (ICH) and plays an important role in secondary brain …
following intracerebral hemorrhage (ICH) and plays an important role in secondary brain …
NOX5: molecular biology and pathophysiology
New Findings What is the topic of this review? This review provides a comprehensive
overview of Nox5 from basic biology to human disease and highlights unique features of this …
overview of Nox5 from basic biology to human disease and highlights unique features of this …
From form to function: the role of Nox4 in the cardiovascular system
F Chen, S Haigh, S Barman, DJR Fulton - Frontiers in physiology, 2012 - frontiersin.org
The NADPH oxidase (Nox) family of proteins is comprised of seven members, including
Noxes1–5 and the Duoxes 1 and 2. Nox4 is readily distinguished from the other Nox …
Noxes1–5 and the Duoxes 1 and 2. Nox4 is readily distinguished from the other Nox …
Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension
Excessive levels of reactive oxygen species (ROS) and increased expression of NADPH
oxidases (Nox) have been proposed to contribute to pulmonary artery hypertension (PAH) …
oxidases (Nox) have been proposed to contribute to pulmonary artery hypertension (PAH) …
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia
Although age-dependent effects on blood pressure (BP) have been reported, they have not
been systematically investigated in large-scale genome-wide association studies (GWASs) …
been systematically investigated in large-scale genome-wide association studies (GWASs) …