Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders
characterized by social deficits and stereotyped behaviors. Despite intensive research, its …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

Inhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The
communication-as well as the connectivity-between corticolimbic regions of the brain are …

Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …

In mammals, excitatory cortical neurons develop from the proliferative epithelium and
progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the …

Genome-wide association studies (GWAS) of major depression and its relevant biological
phenotypes have been extensively conducted in large samples, and transcriptome-wide …

Psychiatric conditions marked by impairments in cognitive control often emerge during
adolescence, when the prefrontal cortex (PFC) and its inputs undergo structural and …