Introduction The high failure rate in drug discovery remains a costly and time-consuming
challenge. Improving the odds of success in the early steps of drug development requires …

Drug-induced liver injury remains a frequent reason for drug withdrawal. Accordingly, more
predictive and translational models are required to assess human hepatotoxicity risk. This …

This study evaluates the impact of physiologically relevant oxygen tensions on the response
of HepG2 cells to known inducers and hepatotoxic drugs. We compared transcriptional …

The health risks associated with acute and prolonged exposure to estrogen receptor (ER)
modulators has led to a concerted effort to identify and prioritize potential disruptors present …

Organ-on-chip systems mimic the biochemical, metabolic, genetic, and functional
characteristics of human organs using cell and tissue cultures in controlled …

Microfluidics has shown great potential in a range of biomedical and drug development
applications. Investigating metabolic reactions in vitro via microfluidic devices presents a …

Nanoparticles or nanoscale materials are being synthesized by various techniques with the
advent of sophisticated equipment. Common techniques are: wet chemical techniques …