Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

Alternative splicing of precursor mRNA is an essential mechanism to increase the
complexity of gene expression, and it plays an important role in cellular differentiation and …

Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of
human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely …

RNA editing and splicing are the two major processes that dynamically regulate human
transcriptome diversity. Despite growing evidence of crosstalk between RNA editing …

Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

The number of factors known to participate in the DNA damage response (DDR) has
expanded considerably in recent years to include splicing and alternative splicing factors …

Pre-mRNA splicing is coupled to transcription by RNA polymerase II (RNAP II). We
previously showed that U1 small nuclear ribonucleoprotein (snRNP) associates with RNAP …

Splicing is the removal of intron sequences from pre-mRNA by the spliceosome.
Researchers working in multiple model organisms–notably yeast, insects and mammalian …