Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …

Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies,
because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic …

Peptides play an important role in many fields, including immunology, medical diagnostics,
and drug discovery, due to their high specificity and positive safety profile. However, for their …

As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …