The significance of RB1 in multiple myeloma
Y Wang, R Yang, R Liu, R Yang, Z Lin… - Frontiers in Immunology, 2024 - frontiersin.org
The treatment of multiple myeloma (MM) has significantly advanced; however, the
underlying genetic mechanisms remain elusive. Clonal events and genetic alterations are …
underlying genetic mechanisms remain elusive. Clonal events and genetic alterations are …
[HTML][HTML] Etiology including epigenetic defects of retinoblastoma
L Zhou, Y Tong, BM Ho, J Li, HYE Chan… - Asia-Pacific Journal of …, 2024 - Elsevier
Retinoblastoma (RB), originating from the developing retina, is an aggressive intraocular
malignant neoplasm in childhood. Biallelic loss of RB1 is conventionally considered a …
malignant neoplasm in childhood. Biallelic loss of RB1 is conventionally considered a …
METTL1-mediated tRNA m7G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade
D Du, M Zhou, C Ju, J Yin, C Wang, X Xu… - Journal of Experimental …, 2024 - Springer
Background RNA modifications of transfer RNAs (tRNAs) are critical for tRNA function.
Growing evidence has revealed that tRNA modifications are related to various disease …
Growing evidence has revealed that tRNA modifications are related to various disease …
APC/C prevents a noncanonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor–induced arrest
BL Mouery, EM Baker, L Mei, SC Wolff, CA Mills… - Proceedings of the …, 2024 - pnas.org
Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating
cells, premature S phase entry is avoided by the E3 ubiquitin ligase anaphasepromoting …
cells, premature S phase entry is avoided by the E3 ubiquitin ligase anaphasepromoting …
Self-renewal without niche instruction, feedback or fine-tuning
B MacArthur, P Greulich - bioRxiv, 2024 - biorxiv.org
To self-renew, stem cells must precisely balance proliferation and differentiation. Typically
this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic …
this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic …
Molecular Mechanisms Maintaining Cell Cycle Arrest Induced by Pharmacological CDK4/6 Inhibition
BL Mouery - 2024 - search.proquest.com
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) promote cell cycle entry by
phosphorylating and inactivating the retinoblastoma (RB) protein, allowing for expression of …
phosphorylating and inactivating the retinoblastoma (RB) protein, allowing for expression of …