[HTML][HTML] Infant rhesus macaque brain α-tocopherol stereoisomer profile is differentially impacted by the source of α-tocopherol in infant formula

MJ Kuchan, KM Ranard, P Dey, S Jeon, GY Sasaki… - The Journal of …, 2020 - Elsevier
Background: α-tocopherol (αT) in its natural form [2´ R, 4´ R, 8´ RαT (RRR-αT)] is more
bioactive than synthetic α-tocopherol (all rac-αT). All rac-αT is widely used in infant formulas …

[HTML][HTML] Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians

JP Chan, J Tanprasertsuk, EJ Johnson, P Dey… - Antioxidants, 2024 - mdpi.com
Brain alpha-tocopherol (αT) concentration was previously reported to be inversely
associated with neurofibrillary tangle (NFT) counts in specific brain structures from …

[HTML][HTML] The Impact of LPS on Inflammatory Responses in Alpha-Tocopherol Deficient Mice

MH Seese, AJ Steelman, JW Erdman Jr - Current Developments in Nutrition, 2024 - Elsevier
Background To facilitate the evaluation of vitamin E (α-tocopherol, αT) status on health
outcomes, the αT transfer protein knockout (Ttpa–/–) mouse model has proved to be an …

[HTML][HTML] Brain α-tocopherol concentration and stereoisomer profile alter hippocampal gene expression in weanling mice

JS Rhodes, C Rendeiro, JG Mun, K Du, P Thaman… - The Journal of …, 2020 - Elsevier
Background: Alpha-tocopherol (αT), the bioactive constituent of vitamin E, is essential for
fertility and neurological development. Synthetic αT (8 stereoisomers; all rac-αT) is added to …

α-Tocopherol Depletion Exacerbates Lipopolysaccharide-Induced Reduction of Grip Strength

M Hashida, AJ Steelman, JW Erdman Jr - The Journal of Nutrition, 2024 - Elsevier
Background α-Tocopherol (αT) deficiency causes several neurologic disorders, such as
spinocerebellar ataxia, peripheral neuropathy, and myopathy. Furthermore, decreased …

[HTML][HTML] Natural and synthetic α-tocopherol modulate the neuroinflammatory response in the spinal cord of adult Ttpa-null mice

KM Ranard, MJ Kuchan, JM Juraska… - Current Developments in …, 2021 - Elsevier
Background Vitamin E (α-tocopherol, α-T) deficiency causes neurological pathologies. α-T
supplementation improves outcomes, but the relative bioactivities of dietary natural and …

[HTML][HTML] α-Tocopherol transfer protein-null mice with very low α-tocopherol status do not have an enhanced lipopolysaccharide-induced acute inflammatory response

M Hashida, KM Ranard, AJ Steelman… - Current Developments in …, 2023 - Elsevier
Background The α-tocopherol transfer protein-null (Ttpa−/−) mouse model is a valuable tool
for studying the molecular and functional consequences of vitamin E (α-tocopherol, αT) …

[HTML][HTML] Breeder diet strategies for generating Ttpa-null and wild-type mice with low vitamin E status to assess neurological outcomes

KM Ranard, MJ Kuchan, JW Erdman Jr - Current Developments in Nutrition, 2020 - Elsevier
Studying vitamin E [α-tocopherol (α-T)] metabolism and function in the brain and other
tissues requires an animal model with low α-T status, such as the transgenic α-T transfer …

Experiential legacies of early‐life dietary polyunsaturated fatty acid content on juvenile Walleye: Potential impacts from climate change

LZ Almeida, J Grayson, SA Ludsin… - … of Freshwater Fish, 2023 - Wiley Online Library
Climate‐induced shifts in plankton blooms may alter fish recruitment by affecting the fatty
acid composition of early‐life diets and corresponding performance. Early‐life nutrition may …

The natural occurring RRR-α-Tocopherol and synthetic α-Tocopherol stereoisomers in maternal plasma, cord plasma and breast milk among six regions of China

Z Lou, G Dang, S Wu, K Wu, M Cai - British Journal of Nutrition, 2023 - cambridge.org
The study aimed to investigate RRR-α-Tocopherol and synthetic α-Tocopherol
stereoisomers in maternal plasma, cord plasma and breast milk from different regions of …