Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease
JJ Liu, P Green, JJ Mann, SI Rapoport, ME Sublette - Brain research, 2015 - Elsevier
Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …
Depression and serum low-density lipoprotein: a systematic review and meta-analysis
JE Persons, JG Fiedorowicz - Journal of affective disorders, 2016 - Elsevier
Background A cross-sectional association between depression and serum low-density
lipoprotein (LDL) has been noted in the literature. This study aims to employ meta-analytic …
lipoprotein (LDL) has been noted in the literature. This study aims to employ meta-analytic …
How lipids may affect risk for suicidal behavior
Suicide and nonfatal suicidal behaviors are major causes of mortality and morbidity
worldwide. Variability in rates of suicide and suicidal behaviors within and between …
worldwide. Variability in rates of suicide and suicidal behaviors within and between …
Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis
BackgroundThe etiology of depression remains poorly understood. Changes in blood lipid
levels were reported to be associated with depression and suicide, however study findings …
levels were reported to be associated with depression and suicide, however study findings …
Irving Page Lecture: 5-HT2A serotonin receptor biology: Interacting proteins, kinases and paradoxical regulation
BL Roth - Neuropharmacology, 2011 - Elsevier
5-hydroxytryptamine2A (5-HT2A) serotonin receptors are important pharmacological targets
for a large number of central nervous system and peripheral serotonergic medications. In …
for a large number of central nervous system and peripheral serotonergic medications. In …
Regulation of monoamine transporters and receptors by lipid microdomains: implications for depression
Abstract Lipid microdomains (“rafts”) are dynamic, nanoscale regions of the plasma
membrane enriched in cholesterol and glycosphingolipids, that possess distinctive …
membrane enriched in cholesterol and glycosphingolipids, that possess distinctive …
Serotonin Signaling through Lipid Membranes
LS Kalinichenko, J Kornhuber, S Sinning… - ACS Chemical …, 2024 - ACS Publications
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …
G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics
GP Schmitz, BL Roth - American Journal of Physiology-Cell …, 2023 - journals.physiology.org
G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the
human genome. Even though perhaps 30% of approved medications target GPCRs, they …
human genome. Even though perhaps 30% of approved medications target GPCRs, they …
Lipids and suicide risk
ME Sublette - Behavioral Neurobiology of Suicide and Self Harm, 2020 - Springer
In the search for biomarkers and modifiable risk factors for suicide, lipid status has garnered
considerable interest, although the lipid-suicide connection is not without controversy. Major …
considerable interest, although the lipid-suicide connection is not without controversy. Major …
Vascular smooth muscle cell glycocalyx mediates shear stress-induced contractile responses via a Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) …
The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear
stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of …
stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of …