Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

BACKGROUND Heterogeneity within a given cancer arises from diverse cell types recruited
to the tumor and from genetic and/or epigenetic differences amongst the cancer cells …

The impact of cellular senescence onto aging of organisms is not fully clear, not at least
because of the scarcity of reliable data on the mere frequency of senescent cells in aging …

Although monoclonal in origin, most tumors appear to contain a heterogeneous population
of cancer cells. This observation is traditionally explained by postulating variations in tumor …

The epithelial components of the mammary gland are thought to arise from stem cells with a
capacity for self-renewal and multilineage differentiation. Furthermore, these cells and/or …

An emerging concept in the field of cancer biology is that a rare population of 'tumour stem
cells' exists among the heterogeneous group of cells that constitute a tumour. This concept …

Stem cells have been isolated by their ability to efflux Hoechst 33342 dye and are referred to
as the “side population”(SP). In this study, we used flow cytometry and Hoechst 33342 dye …

▪ Abstract During the development of multicellular organisms, cells become different from
one another by changing their genetic program in response to transient stimuli. Long after …

Activation in transformed cells of normal stem cells' self-renewal pathways might contribute
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …