The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

The prevalence of obesity is a growing health problem. Obesity is strongly associated with
several comorbidities, such as non-alcoholic fatty liver disease, certain cancers, insulin …

White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting
adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis) …

Ex vivo expansion and manipulation of human mesenchymal stem cells are important
approaches to immunoregulatory and regenerative cell therapies. Although these cells show …

Age related increase in body fat mass, visceral adipose tissue (AT), and ectopic fat
deposition are strongly related to worse health conditions in the elderly. Moreover, with …

Image-guided radiofrequency ablation (RFA) is used to treat focal tumors in the liver and
other organs. Despite potential advantages over surgery, hepatic RFA can promote local …

Objective: Accumulation of visceral adipose tissue (VAT) is strongly linked to insulin
resistance. Variations in the size of any adipose depot are determined by alterations in …

Clinical trials with FGF-based drugs report beneficial effects in lipid and bile acid
metabolism, with clinical improvements in dyslipidemia, steatosis, weight loss, and liver …

While fibroblast growth factor (FGF) 1 is expressed in multiple tissues, only adipose-derived
and brain FGF1 have been implicated in the regulation of metabolism. Adipose FGF1 …

Fibroblast growth factor 1 (FGF1) is an autocrine growth factor released from adipose tissue
during over-nutrition or fasting to feeding transition. While local actions underlie the majority …