Valvular heart disease is an important source of cardiovascular morbidity and mortality.
Current prosthetic valve replacement options, such as bioprosthetic and mechanical heart …

Bioprosthetic heart valves (BHVs) largely circumvent the need for long‐term anticoagulation
compared with mechanical valves but are increasingly susceptible to deterioration and …

Abstract Aims Bioprosthetic heart valves (BHVs), made from glutaraldehyde-fixed heterograft
materials, are subject to more rapid structural valve degeneration (SVD) in paediatric and …

Transcatheter aortic valve implantation (TAVI) is now utilised as a less invasive alternative to
surgical aortic valve replacement (SAVR) across the whole spectrum of surgical risk. Long …

Valve replacement is the main therapy for valvular heart disease, in which a diseased valve
is replaced by mechanical heart valve (MHV) or bioprosthetic heart valve (BHV). Since the …

Histologic evaluations revealed excessive accumulations of macrophages and absence of
fibroblastic interstitial cells in explanted bioprosthetic valves. Comprehensive gene and …

Congenital heart diseases (CHDs) frequently impact the right ventricular outflow tract,
resulting in a significant incidence of pulmonary valve replacement in the pediatric …

Biological transport processes near the aortic valve play a crucial role in calcific aortic valve
disease initiation and bioprosthetic aortic valve thrombosis. Hemodynamics coupled with the …

Glutaraldehyde (GA)-treated bovine pericardium is still the gold standard for the fabrication
of bioprostheses needed for the surgical treatment of valvular malfunction. Although …

Either a mechanical or bioprosthetic valve is used in patients undergoing mitral valve
replacement (MVR). However, the optimal mitral prosthesis remains controversial. The aim …