Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

O Koniev, A Wagner - Chemical Society Reviews, 2015 - pubs.rsc.org
Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

W Yang, Y Tao, Y Wu, X Zhao, W Ye, D Zhao… - Nature …, 2019 - nature.com
Phagocytes, including neutrophils and macrophages, have been suggested to function in a
cooperative way in the initial phase of inflammatory responses, but their interaction and …

Quantitative reactivity profiling predicts functional cysteines in proteomes

E Weerapana, C Wang, GM Simon, F Richter, S Khare… - Nature, 2010 - nature.com
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …

Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action

E Linley, SP Denyer, G McDonnell… - Journal of …, 2012 - academic.oup.com
Hydrogen peroxide is extensively used as a biocide, particularly in applications where its
decomposition into non-toxic by-products is important. Although increasing information on …

Chemical methods for mapping cysteine oxidation

LJ Alcock, MV Perkins, JM Chalker - Chemical Society Reviews, 2018 - pubs.rsc.org
Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …

Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor

Y Tian, M Fan, Z Qin, H Lv, M Wang, Z Zhang… - Nature …, 2018 - nature.com
Abstract Hydrogen peroxide (H2O2) is an important signaling molecule in plant
developmental processes and stress responses. However, whether H2O2-mediated …

Reversible inactivation of the tumor suppressor PTEN by H2O2

SR Lee, KS Yang, J Kwon, C Lee, W Jeong… - Journal of Biological …, 2002 - ASBMB
The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the
3′-phosphate of phosphoinositides. Exposure of purified PTEN or of cells to H 2 O 2 …

Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling

HJ Forman, M Torres - American journal of respiratory and critical …, 2002 - atsjournals.org
Phagocytes such as neutrophils and macrophages produce reactive oxygen species (ROS)
during phagocytosis or stimulation with a wide variety of agents through activation of …

Cellular glutathione and thiols metabolism

DA Dickinson, HJ Forman - Biochemical pharmacology, 2002 - Elsevier
Low molecular weight thiol-containing compounds have an essential role in many
biochemical and pharmacological reactions due to the ease with each they are oxidized …