The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Germinal center (GC) B cells undergo affinity selection, which depends on interactions with
CD4+ follicular helper T cells (TFH cells). We found that TFH cells progressed through …

Hematopoietic stem cells (HSCs) self-renew in bone marrow niches formed by
mesenchymal progenitors and endothelial cells expressing the chemokine CXCL12, but …

Lipid mediators influence immunity in myriad ways. For example, circulating sphingosine-1-
phosphate (S1P) is a key regulator of lymphocyte egress,. Although the majority of plasma …

The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …

Acute myeloid leukemia (AML) is initiated and sustained by a hierarchy of leukemia stem
cells (LSCs), and elimination of this cell population is required for curative therapies. Here …

Antibody secreting cells (ASCs) are terminally differentiated cells of the humoral immune
response and must adapt morphologically, transcriptionally, and metabolically to maintain …

Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can
be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that …

Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM
PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility …