Artificial genetic sets composed of size‐expanded base pairs

M Winnacker, ET Kool - Angewandte Chemie International …, 2013 - Wiley Online Library
We describe in this Minireview the synthesis, properties, and applications of artificial genetic
sets built from base pairs that are larger than the natural Watson–Crick architecture. Such …

Design of novel broad‐spectrum antiviral nucleoside analogues using natural bases ring‐opening strategy

X Du, X Yang, J Zhao, J Zhang, J Yu… - Drug Development …, 2024 - Wiley Online Library
The global prevalence of RNA virus infections has presented significant challenges to public
health in recent years, necessitating the expansion of its alternative therapeutic library. Due …

Künstliche genetische Systeme bestehend aus vergrößerten Basenpaaren

M Winnacker, ET Kool - Angewandte Chemie, 2013 - Wiley Online Library
Wir beschreiben in diesem Kurzaufsatz die Synthese, Eigenschaften und Anwendungen von
künstlichen genetischen Systemen, die aus Basenpaaren bestehen, die länger sind als die …

N-vinyl-Nitroimidazole Cycloadditions: potential routes to nucleoside analogues

R Clayton, CA Ramsden - Synthesis, 2005 - thieme-connect.com
Cycloaddition reactions of 4-nitro-and 5-nitro-1-vinylimidazoles have been investigated. The
cycloadducts obtained are potential intermediates for synthesis of purine nucleoside …

A convenient one-pot synthesis of 7-trifluoromethyl-substituted imidazo [4, 5-b] pyridines

T Wesch, VO Iaroshenko, U Groth - Synlett, 2008 - thieme-connect.com
Thieme E-Journals - Synlett / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNLETT Full-text search Full-text search Author …

Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms

K Furukawa, M Hattori, T Ohki, Y Kitamura… - Bioorganic & medicinal …, 2012 - Elsevier
The development of a reliable and simple method for detecting single nucleotide
polymorphisms (SNPs), common genetic variations in the human genome, is currently an …

Facile Synthesis of Fluorinated 1-Desazapurines

VO Iaroshenko, DV Sevenard, DM Volochnyuk… - …, 2009 - thieme-connect.com
A preparative approach towards 1-desazapurines, starting from 4 (5)-aminoimidazoles and
polyfluoroalkyl-containing 1, 3-CCC-biselectrophiles was developed. As a result, a set of …

Nucleobases with designed patterns of hydrogen bonding

W Fraser - Advances in Heterocyclic Chemistry, 2012 - Elsevier
The chemistry used in key bond-forming steps to prepare nucleobases with designed
patterns of hydrogen bonding is surveyed. Incorporation of the nucleobases into DNA and …

Preparation of 9-substituted pyridine-stretched adenines and hypoxanthines

JA Crawford, W Fraser, CA Ramsden - Synthesis, 2009 - thieme-connect.com
Methylsulfanyl pyridine-stretched adenine and hypoxanthine derivatives have been
prepared via regioselective reaction of a 5-aminoimidazole with 2-(bis …

Routes to N‐vinyl‐nitroimidazoles and N‐vinyl‐deazapurines

R Clayton, CA Ramsden - Journal of heterocyclic chemistry, 2004 - Wiley Online Library
Abstract The preparations of 4‐and 5‐nitro‐1‐vinylimidazole (2 and 7) are described.
Selective reduction of the nitro group using Fe/dil. HCl is achieved for the 4‐nitro derivative …