The chromosome 9p21 (Chr9p21) locus was discovered in 2007 by independent genome-
wide association studies for coronary artery disease. Since then, the locus has been …

Susceptibility to coronary artery disease (CAD) is claimed to be 40% to 60% inherited, but
until recently genetic risk factors predisposing to CAD have been elusive. Comprehensive …

BACKGROUND: Multiple scoring systems have been devised to quantify angiographic
coronary artery disease (CAD) burden, but it is unclear how these scores relate to each …

Background—Free radical scavengers have failed to improve patient outcomes, promoting
the concept that clinically important oxidative stress may be mediated by alternative …

Variation on chromosome 9p21 is associated with risk of coronary artery disease (CAD).
This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle …

Using a phenome-wide association study (PheWAS) approach, we comprehensively tested
genetic variants for association with phenotypes available for 70,061 study participants in …

Rationale: Low circulating progenitor cell numbers and activity may reflect impaired intrinsic
regenerative/reparative potential, but it remains uncertain whether this translates into a …

Background Being unmarried is associated with decreased survival in the general
population. Whether married, divorced, separated, widowed, or never‐married status affects …

Background Mental stress–induced myocardial ischemia (MSIMI) is associated with adverse
prognosis in patients with coronary artery disease (CAD), yet the mechanisms underlying …

Objectives: This study sought to ascertain the relationship of 9p21 locus with: 1)
angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in …