Acute pancreatitis may be associated with both local and systemic complications. Systemic
injury manifests in the form of organ failure, which is seen in approximately 20% of all cases …

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Severe acute pancreatitis (SAP) is an inflammatory disease of the pancreas accompanied
by tissue injury and necrosis. It not only affects the pancreas but also triggers a systemic …

Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3)
inflammasome induces inflammation in response to organ injury, but little is known about its …

Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …

The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due
to a genetic-or environment-based abnormality of intracellular acinar trypsinogen activation …

Islets encapsulated in immunoprotective microcapsules are being proposed as an
alternative for insulin therapy for treatment of type 1 diabetes. Many materials for producing …

Acute pancreatitis (AP) is a potentially life-threatening disease with a wide spectrum of
severity. The overall mortality of AP is approximately 5%. According to the revised Atlanta …

Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their
activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a …

Cell death and inflammation are key pathologic responses of acute pancreatitis (AP), the
leading cause of hospital admissions for gastrointestinal disorders. It is becoming …