Multiplexed imaging enables the simultaneous spatial profiling of dozens of biological
molecules in tissues at single-cell resolution. Extracting biologically relevant information …

Mass cytometry has revolutionized immunophenotyping, particularly in exploratory settings
where simultaneous breadth and depth of characterization of immune populations is needed …

Unmasking the subtleties of the immune system requires both a comprehensive knowledge
base and the ability to interrogate that system with intimate sensitivity. That task, to a …

Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …

CRISPR technologies have begun to revolutionize T cell therapies; however, conventional
CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To …

Several preclinical studies demonstrate that antitumor efficacy of programmed cell death-1
(PD-1)/programmed death-ligand 1 (PD-L1) blockade can be improved by combination with …

Advances in high‐throughput omics technologies are leading plant biology research into the
era of big data. Machine learning (ML) performs an important role in plant systems biology …

Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but
can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of …

Microporous annealed particle (MAP) scaffolds are injectable granular materials comprised
of micron sized hydrogel particles (microgels). The diameter of these microgels directly …

Brain–immune cross-talk and neuroinflammation critically shape brain physiology in health
and disease. A detailed understanding of the brain immune landscape is essential for …