TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

Calcium-dependent chloride channels are required for normal electrolyte and fluid
secretion, olfactory perception, and neuronal and smooth muscle excitability. The molecular …

Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …

The calcium-activated chloride channel anoctamin1 (ANO1; TMEM16A) is fundamental for
the function of epithelial organs. Mice lacking ANO1 expression exhibit transport defects and …

In addition to a direct proinflammatory role, IL-13 has been demonstrated to induce a goblet
cell metaplastic phenotype in the airway epithelium in vivo. We have studied the direct …

Sodium absorption by an amiloride-sensitive channel is the main driving force of lung liquid
clearance at birth and lung edema clearance in adulthood. In this study, we tested whether …

In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

Key Points• Chloride channels are important for proper hydration of the airway surface.•
TMEM16A protein is an important component of calcium‐activated chloride channels.• …

Asthma affects nearly 300 million people worldwide. The majority respond to inhaled
corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to …