The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

A Pišlar, A Mitrović, J Sabotič, U Pečar Fonović… - PLoS …, 2020 - journals.plos.org
Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into
humans, causing highly prevalent and severe respiratory diseases, often with fatal …

What coronavirus 3C‐like protease tells us: from structure, substrate selectivity, to inhibitor design

M Xiong, H Su, W Zhao, H Xie… - Medicinal Research …, 2021 - Wiley Online Library
The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …

[HTML][HTML] Catalytic dyad residues His41 and Cys145 impact the catalytic activity and overall conformational fold of the main SARS-CoV-2 protease 3-chymotrypsin-like …

JC Ferreira, S Fadl, AJ Villanueva, WM Rabeh - Frontiers in chemistry, 2021 - frontiersin.org
Coronaviruses are responsible for multiple pandemics and millions of deaths globally,
including the current pandemic of coronavirus disease 2019 (COVID-19). Development of …

Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines

Z Li, Z Ma, Y Li, S Gao, S Xiao - Microbial pathogenesis, 2020 - Elsevier
Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus
disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in …

Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving STAT2

X Zhu, D Wang, J Zhou, T Pan, J Chen, Y Yang… - Journal of …, 2017 - Am Soc Microbiol
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The
first outbreak of PDCoV was announced from the United States in 2014, followed by reports …

Recognition of divergent viral substrates by the SARS-CoV-2 main protease

EA MacDonald, G Frey, MN Namchuk… - ACS infectious …, 2021 - ACS Publications
The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the cause of coronavirus disease (COVID-19), is an ideal target for pharmaceutical …

Coronaviruses Nsp5 antagonizes porcine gasdermin D-mediated pyroptosis by cleaving pore-forming p30 fragment

F Shi, Q Lv, T Wang, J Xu, W Xu, Y Shi, X Fu, T Yang… - MBio, 2022 - Am Soc Microbiol
Coronaviruses (CoVs) are a family of RNA viruses that typically cause respiratory, enteric,
and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus …

[HTML][HTML] Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO

X Zhu, L Fang, D Wang, Y Yang, J Chen, X Ye… - Virology, 2017 - Elsevier
Porcine deltacoronavirus (PDCoV) causes acute enteric disease and mortality in
seronegative neonatal piglets. Previously we have demonstrated that PDCoV infection …

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2

JC Ferreira, S Fadl, WM Rabeh - Journal of Biological Chemistry, 2022 - ASBMB
3C-like protease (3CLpro) processes and liberates functional viral proteins essential for the
maturation and infectivity of severe acute respiratory syndrome coronavirus 2, the virus …

Identification of novel proteolytically inactive mutations in coronavirus 3C‐like protease using a combined approach

J Zhou, L Fang, Z Yang, S Xu, M Lv, Z Sun… - The FASEB …, 2019 - Wiley Online Library
Coronaviruses (CoVs) infect humans and multiple other animal species, causing highly
prevalent and severe diseases. 3C‐like proteases (3CLpros) from CoVs (also called main …