The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

Cell identity is determined by specific gene expression patterns that are conveyed by
interactions between transcription factors and DNA in the context of chromatin. In …

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it
provides a unique assay to study the interplay between transcription factors and chromatin …

DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) resets the
epigenome to an embryonic-like state. Vitamin C enhances the reprogramming process, but …