Microbial vertical transmission during human pregnancy

N Arora, Y Sadovsky, TS Dermody, CB Coyne - Cell host & microbe, 2017 - cell.com
Congenital infections with pathogens such as Zika virus, Toxoplasma gondii, Listeria
monocytogenes, Treponema pallidium, parvovirus, HIV, varicella zoster virus, Rubella …

Formation and size distribution of self-assembled vesicles

C Huang, D Quinn, Y Sadovsky… - Proceedings of the …, 2017 - National Acad Sciences
When detergents and phospholipid membranes are dispersed in aqueous solutions, they
tend to self-assemble into vesicles of various shapes and sizes by virtue of their hydrophobic …

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

M Wu, Y Ouyang, Z Wang, R Zhang… - Proceedings of the …, 2017 - National Acad Sciences
Exosomes are nanoscale extracellular vesicles that play an important role in many
biological processes, including intercellular communications, antigen presentation, and the …

Unique microRNA signals in plasma exosomes from pregnancies complicated by preeclampsia

H Li, Y Ouyang, E Sadovsky, WT Parks, T Chu… - …, 2020 - Am Heart Assoc
Although preeclampsia is a common and serious complication of pregnancy, insight into its
pathobiology and diagnosis is lacking. Circulating plasma exosomes, which contain RNA …

LPS induces active HMGB1 release from hepatocytes into exosomes through the coordinated activities of TLR4 and caspase-11/GSDMD signaling

W Li, M Deng, PA Loughran, M Yang, M Lin… - Frontiers in …, 2020 - frontiersin.org
High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of
lethality when released extracellularly during sepsis. The major source of circulating HMGB1 …

Early human trophoblast development: from morphology to function

M Gauster, G Moser, S Wernitznig, N Kupper… - Cellular and Molecular …, 2022 - Springer
Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …

Placental Exosomes as Biomarkers for Maternal Diseases: Current Advances in Isolation, Characterization, and Detection

CM Nguyen, M Sallam, MS Islam, K Clack, N Soda… - ACS …, 2023 - ACS Publications
Serving as the interface between fetal and maternal circulation, the placenta plays a critical
role in fetal growth and development. Placental exosomes are small membrane-bound …

Circulating extracellular vesicles in healthy and pathological pregnancies: A scoping review of methodology, rigour and results

MVC Barnes, P Pantazi, B Holder - Journal of Extracellular …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) play a crucial role in pregnancy, revealed by the presence of
placental‐derived EVs in maternal blood, their in vitro functionality, and their altered cargo in …

MicroRNA signaling in embryo development

N Gross, J Kropp, H Khatib - Biology, 2017 - mdpi.com
Expression of microRNAs (miRNAs) is essential for embryonic development and serves
important roles in gametogenesis. miRNAs are secreted into the extracellular environment …

Extracellular vesicles as innovative tool for diagnosis, regeneration and protection against neurological damage

P Andjus, M Kosanović, K Milićević, M Gautam… - International journal of …, 2020 - mdpi.com
Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may
represent a new biosignaling paradigm. According to the mode of biogenesis, size and …