Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Long noncoding RNAs (lncRNAs) are a large and diverse class of genes in eukaryotic
genomes that contribute to a variety of regulatory processes. Functionally characterized …

Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by
activating temporally defined transcriptional cascades. Whether concurrent changes in the …

Immunotherapies targeting the PD-1/PD-L1 axis have become first-line treatments in
multiple cancers. However, only a limited subset of individuals achieves durable benefits …

Long noncoding RNAs (lncRNAs) are essential regulators of gene expression in eukaryotes.
Despite increasing knowledge on the function of lncRNAs, little is known about their effects …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

Chromium (Cr) is a naturally occurring metallic element found in the Earth's crust. While
trivalent chromium ([Cr (III)] is considered non-carcinogenic, hexavalent chromium [Cr (VI)] …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …