Cytomegalovirus infections after hematopoietic stem cell transplantation: current status and future immunotherapy

SY Cho, DG Lee, HJ Kim - International journal of molecular sciences, 2019 - mdpi.com
Cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT) is
one of the critical infectious complications related to host immune recovery. The spectrum of …

New developments in the management of cytomegalovirus infection after transplantation

A Meesing, RR Razonable - Drugs, 2018 - Springer
Cytomegalovirus (CMV) continues to be one of the most important pathogens that
universally affect solid organ and allogeneic hematopoietic stem cell transplant recipients …

Orthotopic replacement of T-cell receptor α-and β-chains with preservation of near-physiological T-cell function

K Schober, TR Müller, F Gökmen… - Nature biomedical …, 2019 - nature.com
Therapeutic T cells with desired specificity can be engineered by introducing T-cell
receptors (TCRs) specific for antigens of interest, such as those from pathogens or tumour …

Comparable anti-CMV responses of transplant donor and third-party CMV-specific T cells for treatment of CMV infection after allogeneic stem cell transplantation

XY Pei, XF Liu, XY Zhao, M Lv, XD Mo… - Cellular & molecular …, 2022 - nature.com
Adoptive transfer of cytomegalovirus (CMV)-specific cytotoxic T lymphocytes (CMV-CTLs)
from original transplant donors or third-party donors was effective for the treatment of CMV …

Adoptive therapy with cytomegalovirus‐specific T cells for cytomegalovirus infection after haploidentical stem cell transplantation and factors affecting efficacy

XY Pei, XY Zhao, XF Liu, XD Mo, M Lv… - American Journal of …, 2022 - Wiley Online Library
Adoptive therapy with cytomegalovirus (CMV)‐specific cytotoxic T lymphocytes (CMV‐CTLs)
has emerged as an effective method for CMV infection. However, the efficacy reportedly …

Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation

L Stern, HM McGuire, S Avdic… - Nature …, 2022 - nature.com
Human cytomegalovirus reactivation is a major opportunistic infection after allogeneic
haematopoietic stem cell transplantation and has a complex relationship with post …

Viral infections in solid organ transplant recipients: novel updates and a review of the classics

G Haidar, N Singh - Current opinion in infectious diseases, 2017 - journals.lww.com
Ongoing trials to optimize CMV prophylaxis and treatment, and outcomes of HIV-to-HIV
organ transplantation in the United States, have significant implications to optimize …

Adoptive therapy with CMV-specific cytotoxic T lymphocytes depends on baseline CD4+ immunity to mediate durable responses

VA Fabrizio, MI Rodriguez-Sanchez… - Blood …, 2021 - ashpublications.org
Adoptive cell therapy using cytomegalovirus (CMV)-specific cytotoxic T lymphocytes (CMV-
CTLs) has demonstrated efficacy posttransplant. Despite the predicted limited engraftment of …

“Mini” bank of only 8 donors supplies CMV-directed T cells to diverse recipients

I Tzannou, A Watanabe, S Naik, R Daum… - Blood …, 2019 - ashpublications.org
Cytomegalovirus (CMV) infections remain a major cause of morbidity and mortality after
allogeneic hematopoietic stem cell transplantation (HSCT), and standard antiviral therapies …

[HTML][HTML] Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical HSCT

E Zaghi, M Calvi, S Puccio, G Spata, S Terzoli… - JCI insight, 2021 - ncbi.nlm.nih.gov
Haploidentical hematopoietic stem cell transplantation (h-HSCT) represents an efficient
curative approach for patients affected by hematologic malignancies in which the reduced …