Hypotensive snake venom components—a mini-review

O Péterfi, F Boda, Z Szabó, E Ferencz, L Bába - Molecules, 2019 - mdpi.com
Hypertension is considered a major public health issue due to its high prevalence and
subsequent risk of cardiovascular and kidney diseases. Thus, the search for new …

Snake venom components: tools and cures to target cardiovascular diseases

J Frangieh, M Rima, Z Fajloun, D Henrion, JM Sabatier… - Molecules, 2021 - mdpi.com
Cardiovascular diseases (CVDs) are considered as a major cause of death worldwide.
Therefore, identifying and developing therapeutic strategies to treat and reduce the …

Why to study peptides from venomous and poisonous animals?

AN de Oliveira, AM Soares, SL Da Silva - International Journal of Peptide …, 2023 - Springer
Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

[HTML][HTML] Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview

JFD Vidal, MF Schwartz, AV Garay, NF Valadares… - Toxins, 2024 - mdpi.com
Toxicofera reptile venoms are composed of several toxins, including serine proteases.
These proteases are glycosylated enzymes that affect the prey's hemostatic system. Their …

Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South …

PG Gutierres, DR Pereira, NL Vieira… - Frontiers in …, 2022 - frontiersin.org
Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated
with high levels of serum phospholipase A2 (PLA2). VPL has also demonstrated to be a …

Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins

FG Amorim, HT Longhim, CT Cologna… - Journal of Venomous …, 2019 - SciELO Brasil
Abstract Background: Tityus serrulatus venom (Ts venom) is a complex mixture of several
compounds with biotechnological and therapeutical potentials, which highlights the …

[HTML][HTML] Biomedical applications of synthetic peptides derived from venom of animal origin: A systematic review

JL Diaz-Gomez, I Martin-Estal, E Rivera-Aboytes… - Biomedicine & …, 2024 - Elsevier
Abstract Development of therapeutic agents that have fewer adverse effects and have higher
efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections …

Snake Venom Components as Therapeutic Drugs in Ischemic Heart Disease

E Messadi - Biomolecules, 2023 - mdpi.com
Ischemic heart disease (IHD), especially myocardial infarction (MI), is a leading cause of
death worldwide. Although coronary reperfusion is the most straightforward treatment for …

[HTML][HTML] A brief review on the natural history, venomics and the medical importance of bushmaster (Lachesis) pit viper snakes

R Diniz-Sousa, JN Moraes, TM Rodrigues-da-Silva… - Toxicon: X, 2020 - Elsevier
Snakes of the genus Lachesis, commonly known as bushmasters, are the largest venomous
snakes in the Americas. Because these snakes have their habitats in areas of remote forests …

Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom

FA Cordeiro, BM Coutinho, GA Wiezel… - Journal of Venomous …, 2018 - SciELO Brasil
Abstract Background: Lachesis muta rhombeata (Lmr) is the largest venomous snake in
Latin America and its venom contains mainly enzymatic components, such as serine and …