The apparent complexity of the genetic, biochemical, and physiological changes in cancer
cells threatens to stall the elucidation of the origins of cancer and the development of new …

Cancer arises from a stepwise accumulation of genetic changes that liberates neoplastic
cells from the homeostatic mechanisms that govern normal cell proliferation. In humans, at …

Molecular cloning of the transforming gene from a chemically transformed human
osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11. 4 …

Cellular proto-oncogenes can be activated by both point mutations and chromosomal
translocations, suggesting that there may be a direct link between exposure to agents which …

Induction of mammary carcinomas in rats by a single exposure to a carcinogen during
sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the …

Publisher Summary This chapter discusses the advances made in understanding the
mechanisms of action of chemical carcinogens in the light of the recent evidence that …

Publisher Summary This chapter describes the function of RAS genes in the yeast
Saccharomyces cerevisiae and the components of the pathway in which it acts. Yeast RAS …

Several ras genes have been expressed at high levels in Escherichia coli and the resultant
ras proteins were shown to be functional with respect to their well-known specific, high …

We examined the transcription of six cellular oncogenes during the process of compensatory
growth in rat liver after partial hepatectomy. We have previously reported that transcripts of c …

In vitro modification of plasmids containing the human c-Ha-ras1 protooncogene (HRAS1)
with the ultimate carcinogens N-acetoxy-2-acetylaminofluorene and r-7, t-8-dihydroxy-t-9, 10 …