Endogenous biological rhythms with approximately 24-h periodicity are generated by the
circadian clock, in which clock genes coordinate with one another and form a transcriptional …

Being a morning person is a behavioural indicator of a person's underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …

As a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much
attention due to its broad regulatory roles under physiological and pathological conditions …

Circadian clocks are internal timing systems that enable organisms to adjust their behavioral
and physiological rhythms to the daily changes of their environment. These clocks generate …

The cullin-RING E3 ubiquitin ligase CRL4 Cdt2 has emerged as a master regulator of
genome stability, which targets key cell cycle proteins for proteolysis during S phase and …

Circadian rhythm is a roughly 24-h wake and sleep cycle that almost all of the organisms on
the earth follow when they execute their biological functions and physiological activities. The …

Circadian clocks evolved to enable organisms to anticipate and prepare for periodic
environmental changes driven by the day–night cycle. This internal timekeeping mechanism …

Mammalian Cryptochromes, CRY1 and CRY2, function as principal regulators of a
transcription-translation-based negative feedback loop underlying the mammalian circadian …

Neurodegenerative disorders have been shown to exhibit substantial interconnectedness
with circadian rhythmicity. Alzheimer's patients exhibit high degradation of the …

Abstract Cullin-RING ligase 4 (CRL4), a member of the cullin-RING ligase family,
orchestrates a variety of critical cellular processes and pathophysiological events. Recent …