Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

Simple Summary Hypoxia is a common feature of solid tumors and associated with poor
outcome in most cancer types and treatment modalities, including radiotherapy …

Glioblastoma (GBM) is a lethal primary brain tumor characterized by treatment resistance
and inevitable tumor recurrence, both of which are driven by a subpopulation of GBM cancer …

Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage,
HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs …

Under hypoxic conditions, tumor cells undergo a series of adaptations that promote
evolution of a more aggressive tumor phenotype including the activation of DNA damage …

Background A major driver of cancer chromosomal instability is replication stress, the
slowing or stalling of DNA replication. How replication stress and genomic instability are …

Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely
studied for more than six decades. Here we review the importance of hypoxia to …