RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the
fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal …

Ribosomal protein genes are among the most highly expressed genes in most cell types.
Their products are generally essential for ribosome synthesis, which is the cornerstone for …

The RNA world concept is one of the most fundamental pillars of the origin of life theory,–. It
predicts that life evolved from increasingly complex self-replicating RNA molecules,,. The …

Although the mode of action of the ribosomes, the multi-component universal effective
protein-synthesis organelles, has been thoroughly explored, their mere appearance …

Mitochondria have specialized ribosomes that have diverged from their bacterial and
cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

We present a molecular-level model for the origin and evolution of the translation system,
using a 3D comparative method. In this model, the ribosome evolved by accretion …

All known life forms trace back to a last universal common ancestor (LUCA) that witnessed
the onset of Darwinian evolution. One can ask questions about LUCA in various ways, the …

Various independent discoveries have shown that many organic codes exist in living
systems, and this implies that they came into being during the history of life and contributed …