Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …

Serine hydrolases comprise a large family of enzymes that have diverse roles in key cellular
processes, such as lipid metabolism, cell signaling, and regulation of post-translation …

Drug discovery efforts for new covalent inhibitors have drastically increased in the last few
years. The binding mechanism of covalent compounds entails the formation of a chemical …

Serine hydrolases (SHs) comprise a large superfamily of enzymes that play critical roles in
many biological processes. Despite their importance, many SHs remain uncharacterized …

Introduction Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme, that
inactivates endogenous signaling lipids of the fatty acid amide family, including the …

Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the
signalling network system of endocannabinoids, which is associated with various …

Background: The unique ability of piperidine to combine with various molecular fragments
makes it possible to use its chemical structure to create new drugs with potential …

Over the past decade, the idea of targeting the endocannabinoid system to treat anxiety
disorders has received increasing attention. Previous studies focused more on developing …

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are the primary
catabolic enzymes for endocannabinoids, anandamide (AEA), and 2‐arachidonoyl glycerol …

Pharmacological treatment of complex pathologies, such as neurodegenerative diseases
still represents a major challenge, due to the networked pathways involved in their onset …