Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment

J Burgess, M Ferdousi, D Gosal, C Boon… - Oncology and …, 2021 - Springer
Purpose This review provides an update on the current clinical, epidemiological and
pathophysiological evidence alongside the diagnostic, prevention and treatment approach …

Mechanisms of chemotherapy-induced peripheral neuropathy

R Zajączkowska, M Kocot-Kępska, W Leppert… - International journal of …, 2019 - mdpi.com
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side
effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically …

Thalidomide‐induced teratogenesis: History and mechanisms

N Vargesson - Birth Defects Research Part C: Embryo Today …, 2015 - Wiley Online Library
Nearly 60 years ago thalidomide was prescribed to treat morning sickness in pregnant
women. What followed was the biggest man‐made medical disaster ever, where over …

Mechanistic insights for drug repurposing and the design of hybrid drugs for Alzheimer's disease

D Padhi, T Govindaraju - Journal of Medicinal Chemistry, 2022 - ACS Publications
The heterogeneity and complex nature of Alzheimer's disease (AD) is attributed to several
genetic risk factors and molecular culprits. The slow pace and increasing failure rate of …

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

C Therapontos, L Erskine… - Proceedings of the …, 2009 - National Acad Sciences
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of
the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide …

miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS

B Xu, X Niu, X Zhang, J Tao, D Wu, Z Wang, P Li… - Molecular and cellular …, 2011 - Springer
MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging
evidence indicates that miR-143 plays causal roles in cancer tumorigenesis as a tumor …

Anti-angiogenic vanadium pentoxide nanoparticles for the treatment of melanoma and their in vivo toxicity study

S Das, A Roy, AK Barui, MMA Alabbasi, M Kuncha… - Nanoscale, 2020 - pubs.rsc.org
In recent days, vanadium complexes and nanoparticles have received sustainable attention
owing to their vast applications in different fields. In the present study, we report a facile …

Thalidomide‐induced limb defects: resolving a 50‐year‐old puzzle

N Vargesson - Bioessays, 2009 - Wiley Online Library
Despite the recent discovery that thalidomide causes limb defects by targeting highly
angiogenic, immature blood vessels, several challenges still remain and new ones have …

Nanotechnology approaches for prevention and treatment of chemotherapy‐induced neurotoxicity, neuropathy, and cardiomyopathy in breast and ovarian cancer …

S Nevins, CD McLoughlin, A Oliveros, JB Stein… - Small, 2024 - Wiley Online Library
Nanotechnology has emerged as a promising approach for the targeted delivery of
therapeutic agents while improving their efficacy and safety. As a result, nanomaterial …

The teratogenic effects of thalidomide on limbs

N Vargesson - Journal of Hand Surgery (European Volume), 2019 - journals.sagepub.com
Thalidomide remains notorious as a result of the damage it caused to children born to
mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence …