Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products
A Iskander, LJ Yan - Biomolecules, 2022 - mdpi.com
Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a
variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney …
variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney …
[HTML][HTML] WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury
Z Deng, Y Wang, J Liu, H Zhang, L Zhou, H Zhao… - Redox Biology, 2023 - Elsevier
Cisplatin is one of the major causes of acute kidney injury (AKI) in clinical practice, and
ferroptosis is an essential form of cell death in cisplatin-induced AKI (CP-AKI). WW domain …
ferroptosis is an essential form of cell death in cisplatin-induced AKI (CP-AKI). WW domain …
Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53‐Mediated DNA Damage Response
W Deng, X Wei, Z Xie, R Zhang, Z Dong… - Oxidative medicine …, 2022 - Wiley Online Library
Objective. Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney injury
(AKI) in transplanted kidneys. This study was aimed at exploring the role of PLK3 (polo‐like …
(AKI) in transplanted kidneys. This study was aimed at exploring the role of PLK3 (polo‐like …
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice
M Swanson, J Yun, DM Collier, C Seif… - American Journal …, 2023 - journals.physiology.org
Tubular epithelial cell fate following exposure to various types of injurious stimuli can be
decided at distinct cell cycle checkpoints. One such checkpoint occurs during mitosis, known …
decided at distinct cell cycle checkpoints. One such checkpoint occurs during mitosis, known …
Targeting TRIP13 in Wilms tumor with nuclear export inhibitors
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …
improvements in the overall survival, relapse occurs in~ 15% of patients with favorable …