Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse
range of underlying dominant disease processes and pathways despite apparent similarities …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

Rationale: In patients with asthma, X-ray computed tomography (CT) has provided evidence
of thickened airway walls and airway occlusions, but the total number of CT-visible airways …

The airway smooth muscle (ASM) surrounding the airways is dysfunctional in both asthma
and chronic obstructive pulmonary disease (COPD), exhibiting; increased contraction …

Difficult-to-treat asthma affects a minority of adults and children with asthma but represents a
challenging mix of misdiagnosis, multimorbidity, inadequate self-management, severe …

Background A recent study demonstrated a significant correlation between bronchial biopsy
airway remodeling and quantitative computed tomography looking at bronchial wall …

The frenetic development of imaging technology—both hardware and software—provides
exceptional potential for investigation of the lung. In the last two decades, CT was exploited …

Bronchial thermoplasty is a treatment for asthma. It is currently unclear whether its
histopathological impact is sufficiently explained by the proportion of airway wall that is …

Airway remodeling is a hallmark feature of asthma, and one of its key structural changes is
increased airway smooth muscle (ASM) mass and disturbed extracellular matrix (ECM) …